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异基因骨髓移植后免疫抑制患者的线状IgA大疱性皮病

Linear IgA dermatosis in an immunosuppressed patient after allogenic bone marrow transplantation.

作者信息

Schultewolter T, Goos M, Dissemond J

机构信息

Department of Dermatology, University School of Medicine, Essen, Germany.

出版信息

J Eur Acad Dermatol Venereol. 2004 Nov;18(6):721-5. doi: 10.1111/j.1468-3083.2004.01065.x.

Abstract

Linear IgA dermatosis (LAD) is a well-recognized acquired subepidermal bullous autoimmune disease. LAD is characterized by clinical, histopathological and immunopathological findings. We report the case of a 38-year-old man who suffered from a chronic myeloic leukaemia. Although he received immunosuppressive therapy he developed LAD after an allogenic bone marrow transplantation. After diagnosis of LAD was established we started a successful systemic therapy with dapsone, while continuing the preliminary medication. Here we report for the first time on a possible relationship between LAD and bone marrow transplantation in an immunosuppressed patient.

摘要

线状IgA大疱性皮病(LAD)是一种公认的获得性表皮下大疱性自身免疫性疾病。LAD具有临床、组织病理学和免疫病理学特征。我们报告了一例38岁患有慢性粒细胞白血病的男性病例。尽管他接受了免疫抑制治疗,但在异体骨髓移植后仍患上了LAD。在确诊LAD后,我们在继续之前用药的同时,开始使用氨苯砜进行成功的全身治疗。在此我们首次报告了一名免疫抑制患者中LAD与骨髓移植之间可能存在的关系。

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