MacLaren A, Attias M, de Souza W
Laboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS-Bloco G, Ilha do Fundão, Rio de Janeiro, RJ 21941-900, Brazil.
Vet Parasitol. 2004 Nov 10;125(3-4):301-12. doi: 10.1016/j.vetpar.2004.07.006.
The interaction of the tachyzoite stage of Toxoplasma gondii with neutrophils was investigated. Morphological aspects of the initial moments of interaction were analyzed by transmission and scanning electron microscopy, revealing at least three types of reaction from the leukocytes to the parasite: the projection of filopodia, formation of a tunnel-like projection involving the parasite, and invagination of the leukocyte surface at the point of entry. The influence on infectivity of tyrosine kinase, phosphokinase C and phosphatidylinositol 3 kinase cell signaling pathways were studied with the aid of drugs affecting these enzymes in these cells.
研究了刚地弓形虫速殖子阶段与中性粒细胞的相互作用。通过透射电子显微镜和扫描电子显微镜分析了相互作用初始时刻的形态学方面，揭示了白细胞对寄生虫至少三种类型的反应：丝状伪足的伸出、形成涉及寄生虫的隧道样突起以及白细胞表面在进入点处的内陷。借助影响这些细胞中这些酶的药物，研究了酪氨酸激酶、磷酸激酶C和磷脂酰肌醇3激酶细胞信号通路对感染性的影响。
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