Grosshans E, Fourtanier A, Guibaud B
Ann Dermatol Venereol. 1978 Oct;105(10):833-8.
The efficacy of a lotion containing 10 p. 100 ethyl lactate was evaluated in a double-blind clinical trail during 8 weeks. Test subjects were 45 male and female patients with polymorphous juvenile acne. They were divided into three groups and received the following treatments: Group A: oral antibiotic + topical placebo lotion. Group B: oral antibiotic + topical ethyl lactate lotion. Group C: topical ethyl lactate lotion only. The lotions were applied twice daily with a swab of cotton-wool. The antibiotic doses (tetracycline hydrochloride) were decreased as the trial progressed. Patients were examined before the trial, then after 1, 2, 4, 6 and 8 weeks. At each visit, comedones, microcysts, pustules and nodules were counted on a skin surface of 9 cm2. Colour photographs were taken before and at the end of the trial and served for counting inflammatory lesions. Also, at each visit, skin lipids were sampled and analysed by I. R. spectrophotometry in order to asses the effect of the treatments on the free fatty acid/triglyceride ratio. The treatments showed similar effectiveness as regards comedones and microcysts, but only treatments A and B succeeded in reducing the number of inflamed lesions. With respect to the latter, the combined treatment B (oral antibiotic + topical ethyl lactate lotion) was more effective than treatment A (oral antibiotic + topical placebo); both treatments were more effective than treatment C (topical ethyl lactate lotion only). At the end of the trial, all three groups of patients showed significant overall improvement, but acne scores (total number of lesions) did not differ significantly between treatments. When comparing these results with literature data concerning the effects of vitamin A acid and benzoyl peroxide, it appears that ethyl lactate is slightly less effective for topical treatment of acne than vitamin A acid, but slightly more effective than benzoyl peroxide. It should be underlined that ethyl lactate is well tolerated by the skin. Analysis of sebum samples failed to yield evidence of a decrease in the free fatty acid/triglyceride ratio in skin lipids of the patients irrespective of the treatment applied.
在一项为期8周的双盲临床试验中，对一款含有10%乳酸乙酯的洗剂的疗效进行了评估。试验对象为45名患有多形性青少年痤疮的男性和女性患者。他们被分为三组，并接受以下治疗：A组：口服抗生素+外用安慰剂洗剂。B组：口服抗生素+外用乳酸乙酯洗剂。C组：仅外用乳酸乙酯洗剂。用棉签每天两次涂抹洗剂。随着试验进展，抗生素剂量（盐酸四环素）逐渐减少。在试验前、试验开始后1、2、4、6和8周对患者进行检查。每次就诊时，在9平方厘米的皮肤表面计数粉刺、微囊肿、脓疱和结节。在试验开始前和结束时拍摄彩色照片，用于计数炎性皮损。此外，每次就诊时采集皮肤脂质样本，并用红外分光光度法进行分析，以评估治疗对游离脂肪酸/甘油三酯比值的影响。在粉刺和微囊肿方面，各治疗组显示出相似的疗效，但只有A组和B组成功减少了炎性皮损的数量。就后者而言，联合治疗B组（口服抗生素+外用乳酸乙酯洗剂）比治疗A组（口服抗生素+外用安慰剂）更有效；两种治疗均比治疗C组（仅外用乳酸乙酯洗剂）更有效。试验结束时，所有三组患者总体上均有显著改善，但各治疗组之间的痤疮评分（皮损总数）无显著差异。当将这些结果与有关维甲酸和过氧化苯甲酰疗效的文献数据进行比较时，似乎乳酸乙酯在痤疮局部治疗中的效果略逊于维甲酸，但略优于过氧化苯甲酰。应当强调的是，皮肤对乳酸乙酯耐受性良好。无论采用何种治疗方法，对皮脂样本的分析均未发现患者皮肤脂质中游离脂肪酸/甘油三酯比值降低的证据。
