细胞介导的免疫与丙型肝炎病毒感染的结果

Cell-mediated immunity and the outcome of hepatitis C virus infection.

作者信息

Shoukry Naglaa H, Cawthon Andrew G, Walker Christopher M

机构信息

Center for Vaccines and Immunity, Columbus Children's Research Institute, Columbus, Ohio 43205, USA.

出版信息

Annu Rev Microbiol. 2004;58:391-424. doi: 10.1146/annurev.micro.58.030603.123836.

DOI:10.1146/annurev.micro.58.030603.123836

PMID:15487943

Abstract

The hepatitis C virus (HCV) infects approximately three percent of the world's population. Some individuals resolve the infection spontaneously, but the majority develop persistent viremia that often causes progressive liver disease. There is an emerging consensus that cellular immune responses are essential for spontaneous resolution of acute hepatitis C and long-term protection from persistent infection. This review focuses on the recent advances in understanding mechanisms of protective immunity and why they fail in most infected individuals. The distinct yet complementary role of CD4+ and CD8+ T lymphocytes in this process is highlighted.

摘要

丙型肝炎病毒（HCV）感染了全球约3%的人口。一些个体可自发清除感染，但大多数人会发展为持续性病毒血症，这往往会导致进行性肝病。目前已逐渐形成一种共识，即细胞免疫反应对于急性丙型肝炎的自发清除以及预防持续性感染的长期保护至关重要。本综述重点关注了在理解保护性免疫机制方面的最新进展，以及这些机制在大多数感染个体中失效的原因。文中强调了CD4+和CD8+ T淋巴细胞在这一过程中独特而互补的作用。