一个关于具有固定大小基因组的无限无性种群中突变 - 选择平衡的随机模型。

A stochastic model for the mutation-selection balance in an infinite asexual population with a genome of fixed size.

作者信息

Fukshansky Anna

机构信息

Department of Computer Science, Royal Holloway University of London, Egham, Surrey, TW20 0EX, UK.

出版信息

J Theor Biol. 2004 Dec 21;231(4):557-62. doi: 10.1016/j.jtbi.2004.07.011.

DOI:10.1016/j.jtbi.2004.07.011

PMID:15488532

Abstract

A stochastic model is presented which describes the evolution of a genome of a haploid species in an infinite population. The genome is a finite set of elements. The elements are divided into different classes according to their effect on the fitness of the organism. Repeated mutations of the genome elements are permitted, in particular positive mutations are introduced. The distribution of the deleterious elements in the genome with respect to the impact on the fitness is given after the replication step. The steady state is fully described including the distribution and the fitness.

摘要

提出了一种随机模型，该模型描述了单倍体物种基因组在无限种群中的进化过程。基因组是一组有限的元素。这些元素根据它们对生物体适应性的影响被分为不同的类别。允许基因组元素发生重复突变，特别是引入正向突变。在复制步骤之后，给出了基因组中有害元素相对于对适应性影响的分布。完整描述了稳态，包括分布和适应性。