Hofman W F, Riegle G D
Am J Vet Res. 1977 Mar;38(3):403-6.
The effects of giving propiopromazine alone and of electroanesthesia-propiopromazine treatment on thermoregulation (body temperature regulation) were studied in 3 sheep at ambient temperatures of 5, 25, and 35 C. Measures of thermoregulation during a 120-minute treatment and 120-treatment recovery period included rectal temperature, respiratory frequency, respiratory evaporative heat loss, metabolic heat production, multiple skin temperatures, and shivering. During cold exposure (5 C), both the propiopromazine administration and the electroanesthesia-propiopromazine treatment resulted in hypothermia which was attributed to increased peripheral and respiratory heat losses, a transient inhibition of shivering thermogenesis, and a reduction in metabolic heat production. At 35 C ambient temperature, both resulted in hyperthermia caused principally by a reduction in respiratory evaporative heat loss. The effects of electroanesthesia-propiopromazine treatment on thermoregulation appeared to be additive at both the cold (5 C) and the hot (35 C) environments, in that simultaneous administration resulted in a more profound thermoregulatory impairment. Nevertheless, shifts in body temperature during electroanesthesia are partly attributable to phenothiazine premedication.
在环境温度为5℃、25℃和35℃的条件下，对3只绵羊研究了单独给予丙酰丙嗪以及电麻醉-丙酰丙嗪联合治疗对体温调节（体温调控）的影响。在120分钟的治疗期和120分钟的治疗恢复期内，体温调节的测量指标包括直肠温度、呼吸频率、呼吸蒸发散热、代谢产热、多个皮肤温度以及寒颤。在冷暴露（5℃）期间，给予丙酰丙嗪以及电麻醉-丙酰丙嗪联合治疗均导致体温过低，这归因于外周和呼吸散热增加、寒颤产热的短暂抑制以及代谢产热减少。在环境温度为35℃时，两者均导致体温过高，主要是由于呼吸蒸发散热减少所致。在寒冷（5℃）和炎热（35℃）环境中，电麻醉-丙酰丙嗪联合治疗对体温调节的影响似乎具有叠加性，因为同时给药会导致更严重的体温调节损害。然而，电麻醉期间体温的变化部分归因于吩噻嗪类药物的术前用药。
