Lin M T
J Pharmacol Exp Ther. 1979 Jun;209(3):349-51.
The effects of intraperitoneal administration of prostaglandin E1 (PGE1) on thermoregulatory responses were assessed in unanesthetized rats at ambient temperatures (Ta) of 8, 22 and 29 degrees C. The body temperatures, metabolic rate, respiratory evaporative heat loss and vasomotor activity in response to PGE1 were observed. Intraperitoneal administration of PGE1 produced dose-dependent hypothermia at Ta's of both 8 and 22 degrees C. The PGE1 hypothermia was due to both the decreased metabolic rate and the cutaneous vasodilation. However, at a Ta of 29 degrees C, intraperitoneal administration of PGE1 produced no changes in rectal temperature, since the thermoregulatory responses were not affected by PGE1 application at this Ta. The data indicate that peripheral administration of PGE1 decreases metabolic heat production and increases heat loss, which leads to hypothermia in rats, in contrast to hyperthermia seen after central administration.
在8、22和29摄氏度的环境温度（Ta）下，对未麻醉大鼠评估腹腔注射前列腺素E1（PGE1）对体温调节反应的影响。观察了PGE1作用下的体温、代谢率、呼吸蒸发散热和血管舒缩活动。在8和22摄氏度的Ta时，腹腔注射PGE1产生剂量依赖性体温过低。PGE1导致的体温过低是由于代谢率降低和皮肤血管舒张。然而，在29摄氏度的Ta时，腹腔注射PGE1未引起直肠温度变化，因为在此Ta下体温调节反应不受PGE1应用的影响。数据表明，与中枢给药后出现的体温过高相反，外周给予PGE1会降低代谢产热并增加散热，从而导致大鼠体温过低。
