用于神经修复的体干细胞研究：当前证据与新观点
Somatic stem cell research for neural repair: current evidence and emerging perspectives.
作者信息
Corti Stefania, Locatelli Federica, Papadimitriou Dimitra, Strazzer Sandra, Comi G P
机构信息
Centro Dino Ferrari, Dipartimento di Scienze Neurologiche, Università degli Studi di Milano, I.R.C.C.S. Ospedale Maggiore Policlinico, Milano 20122, Italy.
出版信息
J Cell Mol Med. 2004 Jul-Sep;8(3):329-37. doi: 10.1111/j.1582-4934.2004.tb00322.x.
Recent evidence supports the existence of adult mammalian stem cell subpopulations, particularly within the bone marrow, that may be able to "transdifferentiate" across tissue lineage boundaries, thus offering an accessible source for therapeutic applications even for neural tissue repair. However, the difficulties in reproducing some experimental data, the rarity of the transdifferentiation events and observations that cell fusion may be an alternative explanation argue against the idea of stem cell plasticity. Investigations going beyond descriptive experiments and more mechanicistic approaches may provide a more solid foundation to adult stem cell therapeutic potential.
最近的证据支持成年哺乳动物干细胞亚群的存在，尤其是在骨髓中，这些亚群可能能够跨组织谱系边界“转分化”，从而为治疗应用提供了一个可利用的来源，甚至可用于神经组织修复。然而，在重现一些实验数据方面存在困难，转分化事件罕见，以及有观察表明细胞融合可能是另一种解释，这些都对干细胞可塑性的观点提出了质疑。超越描述性实验和采用更具机械论方法的研究可能会为成体干细胞的治疗潜力提供更坚实的基础。
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