基因罗盘：一个用于分析任何基因组基因表达的通用系统。

GenCompass: a universal system for analysing gene expression for any genome.

作者信息

Luscombe Nicholas M, Babu M Madan

机构信息

Department of Molecular Biophysics and Biochemistry, Yale University, PO Box 208114, New Haven, CT 06520-8114, USA.

出版信息

Trends Biotechnol. 2004 Nov;22(11):552-5. doi: 10.1016/j.tibtech.2004.08.013.

DOI:10.1016/j.tibtech.2004.08.013

PMID:15491796

Abstract

Microarrays have become indispensable tools for studying the gene expression of particular organisms on a genomic scale. However, despite its widespread use, there are several draw-backs to the current technology. First, it requires prior knowledge of the DNA sequence encoded in the organism of interest, and second, chips must be designed specifically for each genome, greatly increasing the initial cost incurred in manufacturing the arrays.

摘要

微阵列已成为在基因组规模上研究特定生物体基因表达的不可或缺的工具。然而，尽管其被广泛使用，但当前技术仍存在一些缺点。首先，它需要对感兴趣的生物体中编码的DNA序列有先验知识，其次，芯片必须针对每个基因组进行专门设计，这大大增加了制造阵列的初始成本。