血小板与癌症的相互作用：肿瘤细胞诱导血小板聚集的机制与药理学
Platelet--cancer interactions: mechanisms and pharmacology of tumour cell-induced platelet aggregation.
作者信息
Jurasz Paul, Alonso-Escolano David, Radomski Marek W
机构信息
Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas-Houston, Houston, TX, USA.
出版信息
Br J Pharmacol. 2004 Dec;143(7):819-26. doi: 10.1038/sj.bjp.0706013. Epub 2004 Oct 18.
Abstract
During haematogenous metastasis, cancer cells migrate to the vasculature and interact with platelets resulting in tumour cell-induced platelet aggregation (TCIPA). We review: 1. The biological and clinical significance of TCIPA; 2. Molecular mechanisms involved in platelet aggregation by cancer cells; 3. Strategies for pharmacological regulation of these interactions. We conclude that pharmacological regulation of platelet-cancer cell interactions may reduce the impact of TCIPA on cancer biology.
摘要
在血行转移过程中，癌细胞迁移至脉管系统并与血小板相互作用，导致肿瘤细胞诱导的血小板聚集（TCIPA）。我们综述了：1. TCIPA的生物学和临床意义；2. 癌细胞诱导血小板聚集所涉及的分子机制；3. 对这些相互作用进行药理调节的策略。我们得出结论，对血小板-癌细胞相互作用的药理调节可能会降低TCIPA对癌症生物学的影响。
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本文引用的文献
1
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JAMA. 2004 May 26;291(20):2433-40. doi: 10.1001/jama.291.20.2433.
2
Matrix metalloproteinase-2 contributes to increased platelet reactivity in patients with metastatic prostate cancer: a preliminary study.基质金属蛋白酶-2导致转移性前列腺癌患者血小板反应性增加：一项初步研究。
Thromb Res. 2003;112(1-2):59-64. doi: 10.1016/j.thromres.2003.10.012.
3
Low-molecular-weight heparins: beyond thrombosis in the management of the cancer patient.低分子量肝素：癌症患者管理中超越血栓形成的应用
Semin Thromb Hemost. 2003 Dec;29 Suppl 1:13-5. doi: 10.1055/s-2003-45412.
4
Correlation of platelet count with second-look laparotomy results and disease progression in patients with advanced epithelial ovarian cancer.晚期上皮性卵巢癌患者血小板计数与二次剖腹探查结果及疾病进展的相关性
Obstet Gynecol. 2004 Jan;103(1):82-5. doi: 10.1097/01.AOG.0000102703.21556.0B.
5
Membrane type-1 matrix metalloproteinase stimulates tumour cell-induced platelet aggregation: role of receptor glycoproteins.膜型-1基质金属蛋白酶刺激肿瘤细胞诱导的血小板聚集：受体糖蛋白的作用。
Br J Pharmacol. 2004 Jan;141(2):241-52. doi: 10.1038/sj.bjp.0705606. Epub 2003 Dec 22.
6
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7
Coagulopathic complications in breast cancer.乳腺癌的凝血异常并发症
Cancer. 2003 Oct 15;98(8):1578-86. doi: 10.1002/cncr.11702.
8
Selectin-mucin interactions as a probable molecular explanation for the association of Trousseau syndrome with mucinous adenocarcinomas.选择素-黏蛋白相互作用可能是特鲁索综合征与黏液腺癌关联的分子学解释。
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9
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10
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