Jurasz Paul, Alonso-Escolano David, Radomski Marek W
Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas-Houston, Houston, TX, USA.
Br J Pharmacol. 2004 Dec;143(7):819-26. doi: 10.1038/sj.bjp.0706013. Epub 2004 Oct 18.
During haematogenous metastasis, cancer cells migrate to the vasculature and interact with platelets resulting in tumour cell-induced platelet aggregation (TCIPA). We review: 1. The biological and clinical significance of TCIPA; 2. Molecular mechanisms involved in platelet aggregation by cancer cells; 3. Strategies for pharmacological regulation of these interactions. We conclude that pharmacological regulation of platelet-cancer cell interactions may reduce the impact of TCIPA on cancer biology.
在血行转移过程中,癌细胞迁移至脉管系统并与血小板相互作用,导致肿瘤细胞诱导的血小板聚集(TCIPA)。我们综述了:1. TCIPA的生物学和临床意义;2. 癌细胞诱导血小板聚集所涉及的分子机制;3. 对这些相互作用进行药理调节的策略。我们得出结论,对血小板-癌细胞相互作用的药理调节可能会降低TCIPA对癌症生物学的影响。