Gumus Tufan, Umman Veysel, Cetin Bekir, Uguz Alper
Department of General Surgery, Faculty of Medicine, Ege University, 35040 Izmir, Türkiye.
Department of General Surgery, Faculty of Medicine, Yeditepe University, 34755 Istanbul, Türkiye.
Medicina (Kaunas). 2025 Apr 1;61(4):639. doi: 10.3390/medicina61040639.
: This study aimed to determine whether albumin levels and the ratios of key biochemical markers, including the hemoglobin, albumin, lymphocyte, and platelet (HALP score) and lymphocyte/C-reactive protein ratio (LCR), can predict survival and recurrence in patients with pancreatic adenocarcinoma. : A total of 87 patients who underwent surgery for pancreatic adenocarcinoma in our clinic between January 2017 and December 2021 were included. Preoperative albumin levels, HALP scores, and LCR values were calculated and analyzed to evaluate their predictive value for pathological findings in the early postoperative period. : The mean age of the study population was 64.8 ± 9.6 years; 59 patients (67.8%) were male, and 28 (32.2%) were female. The cut-off values for HALP, LCR, and albumin were 34.4, 0.61, and 38.55, respectively. Patients with low HALP scores had significantly shorter overall survival than those with high scores (15.8 vs. 19.3 months; < 0.01). Similarly, patients with low LCR scores showed shorter survival than those with high scores (17.8 vs. 18.5 months; < 0.01). High albumin levels were associated with significantly longer survival compared to low albumin levels (16.3 vs. 14.6 months; < 0.01). : Low HALP scores and low albumin levels were identified as significant independent prognostic factors for both disease-free and overall survival in patients with pancreatic adenocarcinoma.
本研究旨在确定白蛋白水平以及关键生化标志物的比值,包括血红蛋白、白蛋白、淋巴细胞和血小板(HALP评分)以及淋巴细胞/ C反应蛋白比值(LCR),是否能够预测胰腺腺癌患者的生存和复发情况。
纳入了2017年1月至2021年12月期间在我院接受胰腺腺癌手术的87例患者。计算并分析术前白蛋白水平、HALP评分和LCR值,以评估它们对术后早期病理结果的预测价值。
研究人群的平均年龄为64.8±9.6岁;59例(67.8%)为男性,28例(32.2%)为女性。HALP、LCR和白蛋白的临界值分别为34.4、0.61和38.55。HALP评分低的患者总生存期明显短于评分高的患者(15.8个月对19.3个月;P<0.01)。同样,LCR评分低的患者生存期短于评分高的患者(17.8个月对18.5个月;P<0.01)。与低白蛋白水平相比,高白蛋白水平与显著更长的生存期相关(16.3个月对14.6个月;P<0.01)。
低HALP评分和低白蛋白水平被确定为胰腺腺癌患者无病生存期和总生存期的重要独立预后因素。