Ozden Ali, Bozdayi Gülendam, Ozkan Muhip, Köse Kenan S
Department of Gastroenterology, School of Medicine, Ankara University, Ankara, Turkey.
Turk J Gastroenterol. 2004 Sep;15(3):156-8.
BACKGROUND/AIMS: This study was undertaken to evaluate changes in the seroepidemiological pattern of Helicobacter pylori in a group of Turkish children over a span of 10 years.
A total of 403 (219+184) serum samples were obtained from a primary school located in the urban part of Ankara in 1990 and 2000. All of the samples were from healthy students aged 7-14 (in 1990, n= 219, 109 females; and in 2000, n= 184, 90 females).
All serum samples were assayed for Helicobacter pylori IgG by means of enzyme-linked immunosorbent assay. The overall prevalence of Helicobacter pylori antibodies was 78.5% in 1990 and 66.3% in 2000. The prevalence of Helicobacter pylori was found to be decreasing over a time span of 10 years (p<0.01). While the most susceptible age group to Helicobacter pylori in 1990 was 10 years (89.5%), in 2000 the susceptible age group was 8 years (85.0%).
Our data suggest that the seroprevalence of Helicobacter pylori infection seems to have decreased during the last 10 years in Turkey. This change may be attributable to the changes in environmental condition and socioeconomic development that have taken place in the country.
背景/目的：本研究旨在评估一组土耳其儿童在10年期间幽门螺杆菌血清流行病学模式的变化。
1990年和2000年从安卡拉市区的一所小学共采集了403份（219份 + 184份）血清样本。所有样本均来自7 - 14岁的健康学生（1990年，n = 219，女性109名；2000年，n = 184，女性90名）。
采用酶联免疫吸附测定法对所有血清样本检测幽门螺杆菌IgG。1990年幽门螺杆菌抗体的总体患病率为78.5%，2000年为66.3%。发现幽门螺杆菌患病率在10年期间呈下降趋势（p < 0.01）。1990年对幽门螺杆菌最易感的年龄组是10岁（89.5%），2000年易感年龄组是8岁（85.0%）。
我们的数据表明，过去10年土耳其幽门螺杆菌感染的血清流行率似乎有所下降。这种变化可能归因于该国环境条件和社会经济发展的变化。
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