Chen Jie, Bu Xiao Lin, Wang Qi Yi, Hu Pin Jin, Chen Min Hu
Department of Gastroenterology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Helicobacter. 2007 Apr;12(2):164-9. doi: 10.1111/j.1523-5378.2007.00487.x.
Prevalence of Helicobacter pylori infection is inversely associated with socioeconomic conditions. The aim of the study was to evaluate changes in the seroprevalence of H. pylori infection during 1993-2003 in Guangzhou, a representative city of southern China with quick improvement in socioeconomy.
From March to August 2003, sera were collected from 1471 healthy persons (760 male and 711 female subjects, aged 3-92 years) undergoing annual routine health examination in Guangzhou. H. pylori infection was checked by enzyme-linked immunosorbent assay (ELISA).
In 2003, the overall prevalence rate of H. pylori infection was 47% with no gender difference (p > .05). Children aged 1-5 years had the prevalence rate of 19.4%. The prevalence rate then increased steadily with annual infection rate of approximately 1% after this age, reaching a plateau of approximately 55% after the age of 50 years. The peak seroprevalence rate was 63.2% at 40-50 years. Comparing the prevalence rate of H. pylori infection in 2003 with data obtained in 1993, statistically significant decrease of H. pylori infection rate ranged from 11.4 to 18.0% in different age groups was found. The overall age-standardized H. pylori seroprevalence rate was 62.5% in 1993 and 49.3% in 2003. The seroprevalence of H. pylori was found to be significantly decreased over a time span of 10 years (p < .001).
Our data suggest that the seroprevalence of H. pylori infection has significantly decreased during the 10-year period in Guangzhou. This change may be attributable to the improvement in socioeconomic conditions in this city.
幽门螺杆菌感染率与社会经济状况呈负相关。本研究旨在评估1993年至2003年期间，中国南方一个社会经济快速发展的代表性城市广州幽门螺杆菌感染血清流行率的变化。
2003年3月至8月，从广州市1471名接受年度常规健康检查的健康人（760名男性和711名女性，年龄3至92岁）中采集血清。采用酶联免疫吸附试验（ELISA）检测幽门螺杆菌感染情况。
2003年，幽门螺杆菌感染总体患病率为47%，无性别差异（p>.05）。1至5岁儿童的患病率为19.4%。此后患病率随年龄稳步上升，年感染率约为1%，50岁后达到约55%的平台期。40至50岁时血清流行率峰值为63.2%。将2003年幽门螺杆菌感染率与1993年的数据进行比较，发现不同年龄组幽门螺杆菌感染率有统计学意义的下降，范围为11.4%至18.0%。1993年总体年龄标准化幽门螺杆菌血清流行率为62.5%，2003年为49.3%。发现幽门螺杆菌血清流行率在10年期间显著下降（p<.001）。
我们的数据表明，广州在10年期间幽门螺杆菌感染血清流行率显著下降。这一变化可能归因于该市社会经济状况的改善。
