脑瘫的病因

Etiology of cerebral palsy.

作者信息

Meberg Alf, Broch Harald

机构信息

Department of Paediatrics, Vestfold Hospital Tønsberg, Norway.

出版信息

J Perinat Med. 2004;32(5):434-9. doi: 10.1515/JPM.2004.143.

DOI:10.1515/JPM.2004.143

PMID:15493722

Abstract

AIMS

To register the prevalence of cerebral palsy (CP) and determine etiological factors for the condition.

METHODS

Population based study with registration of CP-cases in children born during the 30-year period 1970-99. Cases with postneonatal etiology were excluded.

RESULTS

166 CP-cases were registered among 70 824 children, a prevalence of 2.3 per 1000 live born infants. The prevalence did not change significantly during the period. 66 (40%) were low birthweight infants (LBWIs; <2500 g), and 100 (60%) normal birthweight infants (NBWIs; > or = 2500 g). The origin was classified as prenatal in 37 (22%), perinatal/neonatal in 78 (47%) and unclassifiable in 51 (31 %). In LBWIs 39/66 (59%) had a perinatal/neonatal etiology, most frequently intra- or periventricular hemorrhages (IVH/PVH) and/or periventricular leukomalacia (PVL) or cerebral infarctions (CI) (17; 44%). In NBWIs 39/100 (39%) had a perinatal etiology, most frequently hypoxic-ischemic encephalopathy (HIE) (31; 79%).

CONCLUSIONS

In a substantial percentage of CP-cases perinatal/neonatal brain injury was classified as the cause. Among these IVH/PVH/PVL/CI dominated in LBWIs, while HIE dominated in NBWIs. Our data may point to preventability of a larger part of CP than earlier suggested.

摘要

目的

登记脑瘫（CP）的患病率并确定其病因。

方法

基于人群的研究，登记1970 - 1999年30年间出生儿童中的CP病例。排除新生儿期后病因的病例。

结果

在70824名儿童中登记了166例CP病例，每1000例活产婴儿中的患病率为2.3。在此期间患病率无显著变化。66例（40%）为低体重儿（LBWIs；<2500克），100例（60%）为正常体重儿（NBWIs；≥2500克）。病因分类为产前的有37例（22%），围产期/新生儿期的有78例（47%），无法分类的有51例（31%）。在低体重儿中，39/66例（59%）有围产期/新生儿期病因，最常见的是脑室内或脑室周围出血（IVH/PVH）和/或脑室周围白质软化（PVL）或脑梗死（CI）（17例；44%）。在正常体重儿中，39/100例（39%）有围产期病因，最常见的是缺氧缺血性脑病（HIE）（31例；79%）。