作为手性配体的C2对称双环[2.2.2]辛二烯：它们在铑催化的N-甲苯磺酰基芳基亚胺不对称芳基化反应中的高性能。
C2-symmetric bicyclo[2.2.2]octadienes as chiral ligands: their high performance in rhodium-catalyzed asymmetric arylation of N-tosylarylimines.
作者信息
Tokunaga Norihito, Otomaru Yusuke, Okamoto Kazuhiro, Ueyama Kazuhito, Shintani Ryo, Hayashi Tamio
机构信息
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
出版信息
J Am Chem Soc. 2004 Oct 27;126(42):13584-5. doi: 10.1021/ja044790e.
PMID:15493893
Abstract
Asymmetric synthesis of diarylmethylamines with high enantioselectivity (95-99% ee) was realized by use of a new C2-symmetric diene ligand, (1R,4R)-2,5-diphenylbicyclo[2.2.2]octa-2,5-diene (Ph-bod*), for the rhodium-catalyzed asymmetric arylation of N-tosylarylimines with arylboroxines.
摘要
通过使用一种新型的C2对称二烯配体，即(1R,4R)-2,5-二苯基双环[2.2.2]辛-2,5-二烯（Ph-bod*），实现了对映选择性高（对映体过量95-99%）的二芳基甲胺的不对称合成，用于铑催化的N-甲苯磺酰基芳基胺与芳基硼酸酯的不对称芳基化反应。
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