铑-二烯配合物催化二甲基锌对N-对甲苯磺酰基芳基亚胺的不对称加成反应用于合成手性1-芳基乙胺。
Asymmetric addition of dimethylzinc to N-tosylarylimines catalyzed by a rhodium-diene complex toward the synthesis of chiral 1-arylethylamines.
作者信息
Nishimura Takahiro, Yasuhara Yuichi, Hayashi Tamio
机构信息
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.
出版信息
Org Lett. 2006 Mar 2;8(5):979-81. doi: 10.1021/ol060213e.
PMID:16494489
Abstract
A rhodium complex coordinated with a chiral diene, (R,R)-2,5-diphenylbicyclo[2.2.2]octa-2,5-diene (Ph-bod), catalyzed the asymmetric addition of dimethylzinc to N-tosylarylimines to give high yields of chiral 1-aryl-1-ethylamines with high enantioselectivity (94-98% ee).
摘要
一种与手性二烯（R,R）-2,5-二苯基双环[2.2.2]辛-2,5-二烯（Ph-bod）配位的铑配合物，催化二甲基锌对N-对甲苯磺酰基芳基亚胺的不对称加成反应，以高对映选择性（对映体过量值为94 - 98%）高产率地得到手性1-芳基-1-乙胺。
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