铑催化环状亚胺的亲核烯丙基化反应中烯丙基铑中间体的异构化

The isomerization of allylrhodium intermediates in the rhodium-catalyzed nucleophilic allylation of cyclic imines.

作者信息

Hepburn Hamish B, Lam Hon Wai

机构信息

EaStCHEM, School of Chemistry, University of Edinburgh, Joseph Black Building, The King's Buildings, West Mains Road, Edinburgh, EH9 3JJ (UK) http://www.nottingham.ac.uk/∼pczhl; School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD (UK).

出版信息

Angew Chem Int Ed Engl. 2014 Oct 20;53(43):11605-10. doi: 10.1002/anie.201407233. Epub 2014 Sep 9.

Allylrhodium species generated from potassium allyltrifluoroborates can undergo isomerization by 1,4-rhodium(I) migration to give more complex isomers, which then react with cyclic imines to provide products with up to three new stereochemical elements. High enantioselectivities are obtained using chiral diene-rhodium complexes.