多发性原发性软组织肉瘤。

Multiple primary soft tissue sarcomas.

作者信息

Grobmyer Stephen R, Luther Neal, Antonescu Cristina R, Singer Samuel, Brennan Murray F

机构信息

Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

出版信息

Cancer. 2004 Dec 1;101(11):2633-5. doi: 10.1002/cncr.20679.

DOI:10.1002/cncr.20679

PMID:15494976

Abstract

BACKGROUND

The synchronous or metachronous development of multiple primary soft tissue sarcomas (STS) of different histopathology has been reported only in isolated case reports.

METHODS

The records of patients who developed multiple primary STS and who were treated at a tertiary cancer center between 1982 and 2003 were reviewed.

RESULTS

Nine patients with multiple primary STS were identified, representing 0.2% of all patients who were treated for STS. The median age of patients at the time of initial presentation with sarcoma was 60 years (range, 51-81 years). Most patients in this series (n = 7) had metachronous development of a second primary STS. The incidence of second primary sarcomas in patients who were diagnosed previously with STS (4.0 per 10,000 population per year) was significantly greater than the incidence of primary STS in the general population (3.2 per 100,000 population per year; P < 0.01).

CONCLUSIONS

Although it is an uncommon occurrence, patients who have a history of STS are at an increased risk for the development of a second primary STS.

摘要

背景

不同组织病理学类型的多原发性软组织肉瘤（STS）同步或异时发生的情况仅在个别病例报告中有记载。

方法

回顾了1982年至2003年间在一家三级癌症中心接受治疗的多原发性STS患者的记录。

结果

共识别出9例多原发性STS患者，占所有接受STS治疗患者的0.2%。患者首次出现肉瘤时的中位年龄为60岁（范围51 - 81岁）。该系列中的大多数患者（n = 7）出现了第二原发性STS的异时发生。先前被诊断为STS的患者中第二原发性肉瘤的发病率（每年每10000人中有4.0例）显著高于普通人群中原发性STS的发病率（每年每100000人中有3.2例；P < 0.01）。