与新生儿豆纹状血管病（LSV）发生相关的产前危险因素。

Antenatal risk factors associated with the development of lenticulostriate vasculopathy (LSV) in neonates.

作者信息

Mittendorf Robert, Kuban Karl, Pryde Peter G, Gianopoulos John G, Yousefzadeh David

机构信息

Department of Obstetrics and Gynecology (R.M., J.G.G.), Loyola University Medical Center, Maywood, IL 60153, USA.

出版信息

J Perinatol. 2005 Feb;25(2):101-7. doi: 10.1038/sj.jp.7211212.

DOI:10.1038/sj.jp.7211212

PMID:15496867

Abstract

OBJECTIVE

To determine the antenatal risk factors associated with neonatal lenticulostriate vasculopathy (LSV).

STUDY DESIGN

Women in preterm labor were randomized to magnesium sulfate (MgSO4), other tocolytic, or saline control. The surviving babies underwent head ultrasounds (HUS) (weeks of life 1, 2, and 4) and periodic developmental examinations (months 4, 8, 12, and 18).

RESULTS

Of 140 infants, 17.1% (24) had neonatal intraventricular hemorrhage (IVH), and 10.0% (14) had LSV (half of the latter (7 of 14) had both IVH and LSV). In a regression model in which other risk factors were controlled for, the association between antenatal exposures to tocolytic MgSO4 >or=50 g and LSV were significant (adjusted odds ratio (OR), 8.3; 95% confidence interval (CI), 1.5 to 45.0; p=0.01).

CONCLUSION

Based on our data and their analyses, we infer that antenatal exposure to high-dosage, tocolytic MgSO4 may be associated with LSV.

摘要

目的

确定与新生儿豆纹状血管病变（LSV）相关的产前危险因素。

研究设计

早产女性被随机分为硫酸镁（MgSO4）组、其他宫缩抑制剂组或生理盐水对照组。存活婴儿接受头部超声检查（HUS）（出生后1周、2周和4周）以及定期发育检查（4个月、8个月、12个月和18个月）。

结果

140名婴儿中，17.1%（24例）发生新生儿脑室内出血（IVH），10.0%（14例）发生LSV（后者中有一半（14例中的7例）同时患有IVH和LSV）。在一个控制了其他危险因素的回归模型中，产前暴露于宫缩抑制剂硫酸镁≥50 g与LSV之间的关联具有显著性（校正比值比（OR）为8.3；95%置信区间（CI）为1.5至45.0；p = 0.01）。