与早产儿脑纹状体血管病（LSV）相关的胎盘病理学。
Placental pathology associated with lenticulostriate vasculopathy (LSV) in preterm infants.
机构信息
Department of Pediatrics, Division of Neonatal-Perinatal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Department of Health System Research, Parkland Health and Hospital System, Dallas, TX, USA.
出版信息
J Perinatol. 2023 May;43(5):568-572. doi: 10.1038/s41372-022-01557-5. Epub 2022 Nov 15.
OBJECTIVE
Our aim was to examine the frequency and type of placental abnormalities in neonates with LSV.
STUDY DESIGN
We prospectively reviewed cranial ultrasounds (cUS) from neonates born at ≤32 weeks of gestation at Parkland Hospital between 2012 and 2014. Our cohort included neonates with LSV and gestational age and sex matched controls with normal cUS. We retrieved placental pathology reports retrospectively and compared placental abnormalities in both groups.
RESULTS
We reviewed 1351 cUS from a total of 407 neonates. Placental pathology evaluations were complete for 64/65 (98%) neonates with LSV and 68/70 (97%) matched controls. There were no significant differences for any type of placental abnormities between LSV and control groups. However, infants with highest stage LSV were more likely to have large for gestational age (LGA) placentas (p = 0.01).
CONCLUSION
The association between LSV and LGA placenta may indicate a shared vascular response to an adverse prenatal environment.
目的
本研究旨在探讨小于胎龄儿（LSV）新生儿胎盘异常的频率和类型。
研究设计
我们前瞻性地回顾了 2012 年至 2014 年期间在 Parkland 医院出生且胎龄≤32 周的新生儿的头颅超声（cUS）。我们的队列包括 LSV 新生儿和胎龄及性别匹配的正常 cUS 对照组。我们回顾性地检索了胎盘病理报告，并比较了两组的胎盘异常。
结果
我们共对 407 例新生儿的 1351 例 cUS 进行了评估。64/65（98%）例 LSV 新生儿和 68/70（97%）例匹配对照组的胎盘病理评估完整。LSV 组和对照组之间任何类型的胎盘异常均无显著差异。然而，LSV 分期最高的婴儿更有可能出现大于胎龄儿（LGA）胎盘（p=0.01）。
结论
LSV 与 LGA 胎盘之间的关联可能表明它们对不良产前环境有共同的血管反应。
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