Mungkornasawakul Pitchaya, Pyne Stephen G, Jatisatienr Araya, Lie Wilford, Ung Alison T, Issakul Kritchaya, Sawatwanich Auntika, Supyen Damrat, Jatisatienr Chaiwat
Department of Chemistry, University of Wollongong, New South Wales, 2522, Australia.
J Nat Prod. 2004 Oct;67(10):1740-3. doi: 10.1021/np049791z.
Two new dihydrostemofoline alkaloids, 11(S),12(R)-dihydrostemofoline (3) and stemoburkilline (4), along with stemofoline (1) and 2'-hydroxystemofoline (2) have been isolated from a root extract of Stemona burkillii Prain. The structure and relative configuration of 3 have been determined via spectroscopic data and from comparison with synthetic 11(S),12(S)-dihydrostemofoline (5). The configuration of the exo-cyclic alkene group in 4 is tentively assigned as E on the basis of mechanistic considerations.
从百部（Stemona burkillii Prain）的根提取物中分离出了两种新的二氢百部碱生物碱，11(S),12(R)-二氢百部碱（3）和百部杀虫草碱（4），以及百部碱（1）和2'-羟基百部碱（2）。通过光谱数据并与合成的11(S),12(S)-二氢百部碱（5）进行比较，确定了3的结构和相对构型。基于机理考虑，初步将4中环状外烯烃基团的构型指定为E型。
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