百部植物的植物化学研究：百部叶碱生物碱的分离

Phytochemical studies on Stemona plants: isolation of stemofoline alkaloids.

作者信息

Sastraruji Thanapat, Jatisatienr Araya, Pyne Stephen G, Ung Alison T, Lie Wilford, Williams Morwenna C

机构信息

Department of Chemistry, University of Wollongong, Wollongong, New South Wales 2522, Australia.

出版信息

J Nat Prod. 2005 Dec;68(12):1763-7. doi: 10.1021/np050361y.

DOI:10.1021/np050361y

PMID:16378370

Abstract

Six new stemofoline alkaloids, (2'R)-hydroxystemofoline (5), (3'R)-stemofolenol (6), (3'S)-stemofolenol (7), 1',2'-didehydrostemofoline-N-oxide (8), the first C(19) stemofoline alkaloid, methylstemofoline (9), and the first glycosidated Stemona alkaloid, stemofolinoside (10), and three known alkaloids, (2'S)-hydroxystemofoline (2), (11Z)-1',2'-didehydrostemofoline (3), and (11E)-1',2'-didehydrostemofoline (4), have been isolated from a root extract of an unidentified Stemona species. The structure and relative configuration of these new alkaloids have been determined by spectral data interpretation and from semisynthetic studies.

摘要

从一种未鉴定的百部属植物的根提取物中分离出六种新的百部碱，即(2'R)-羟基百部碱(5)、(3'R)-百部醇(6)、(3'S)-百部醇(7)、1',2'-二脱氢百部碱-N-氧化物(8)（首个C(19)百部碱）、甲基百部碱(9)以及首个糖基化百部生物碱百部醇苷(10)，还有三种已知生物碱，即(2'S)-羟基百部碱(2)、(11Z)-1',2'-二脱氢百部碱(3)和(11E)-1',2'-二脱氢百部碱(4)。这些新生物碱的结构和相对构型已通过光谱数据解析和半合成研究确定。