Kleinman Jack G, Wesson Jeffrey A, Hughes Jeremy
Nephrology Division, Veterans Affairs Medical Center, and Medical College of Wisconsin, Milwaukee 53925, USA.
Nephron Physiol. 2004;98(2):p43-7. doi: 10.1159/000080263.
Osteopontin (OPN) is a phosphorylated protein of wide tissue distribution that is found in association with dystrophic calcification including in the organic matrix of kidney stones. It is a strong inhibitor of crystal formation and growth in vitro, but there is still debate regarding its effects upon crystal adhesion to tubular epithelial cells. In this brief review, we will outline the evidence implicating OPN in stone disease with the primary emphasis being on the interaction of OPN with calcium oxalate (CaOx), the major constituent of calcium containing stones. Finally, preliminary data is presented regarding the amounts and features of OPN present in the urine of stone formers and normal individuals.
骨桥蛋白（OPN）是一种磷酸化蛋白，广泛分布于组织中，与营养不良性钙化有关，包括肾结石的有机基质中。它在体外是晶体形成和生长的强抑制剂，但关于其对晶体与肾小管上皮细胞粘附的影响仍存在争议。在这篇简短的综述中，我们将概述涉及OPN与结石病相关的证据，主要重点是OPN与草酸钙（CaOx）的相互作用，草酸钙是含钙结石的主要成分。最后，给出了关于结石形成者和正常个体尿液中OPN含量及特征的初步数据。
