Sequential therapy using cyclosporine and acitretin for treatment of total body psoriasis.

Systemic sequential therapy using cyclosporine and acitretin is a novel strategy that can provide quick resolution and maintenance in refractory cases of psoriasis. We describe the case of a patient with a psoriatic flare over 98% of his body, despite methotrexate therapy. Implementing sequential therapy with cyclosporine and acitretin maximized the benefit of each treatment and allowed for rapid improvement with minimal risk of toxicity.