Taguma Yoshio, Chiba Shigemi, Sato Hiroshi
Department of Nephrology, Sendai Shakaihoken Hospital.
Nihon Rinsho. 2004 Oct;62(10):1849-55.
MPGN is characterized by its peculiar histological findings; lobular appearance, cellular and mesangial matrix proliferation and double contoured capillary loops. Based on histomorphalogical pattern, three types are subdivided. MPGN may be primary (in most children) or secondary (in most adults) to chronic infections, cryoglobulinemia or systemic autoimmune disorders. Clinical manifestation of typical MPGN is nephrotic range proteinuria associated with microscopic hematuria, showing slowly progressive course. Treatment strategy is composed of exclusion of pathogen, especially in HCV positive MPGN, and intervention to autoimmune mechanism such as alternative-day steroid regimen.
膜增生性肾小球肾炎（MPGN）的特征在于其独特的组织学表现；小叶外观、细胞和系膜基质增生以及双轮廓毛细血管袢。根据组织形态学模式，可细分为三种类型。MPGN可能是原发性的（大多数见于儿童）或继发性的（大多数见于成人），继发于慢性感染、冷球蛋白血症或全身性自身免疫性疾病。典型MPGN的临床表现是肾病范围的蛋白尿伴镜下血尿，呈缓慢进展过程。治疗策略包括排除病原体，特别是在丙型肝炎病毒（HCV）阳性的MPGN中，以及对自身免疫机制进行干预，如隔日使用类固醇疗法。
