二氢吡喃-2,4-二酮自由基清除活性的测定
Determination of the free radical scavenging activity of dihydropyran-2,4-diones.
作者信息
de Souza Laura Cristiane, de Araújo Stella Maris Soares, de Oliveira Imbroisi Dennis
机构信息
LaSO, Laboratório de Síntese Orgânica, Departamento de Química, CCEN, Universidade Federal de Alagoas, 57.072-970 Maceió, AL, Brazil.
出版信息
Bioorg Med Chem Lett. 2004 Dec 6;14(23):5859-61. doi: 10.1016/j.bmcl.2004.09.030.
The antioxidant activities of four synthetic dihydropyran-2,4-diones have been established through the determination of their abilities to inhibit free radicals using DPPH(*) as the stable radical. Whilst all of the compounds exhibited high inhibition percentages, the most active member of the group was 6-phenyl-dihydropyran-2,4-dione. The antioxidant activity of the dihydropyran-2,4-diones is reported here for the first time and extends our knowledge of the range of valuable biological activities associated with this group of compounds.
通过使用DPPH（*）作为稳定自由基来测定四种合成二氢吡喃-2,4-二酮抑制自由基的能力，确定了它们的抗氧化活性。虽然所有化合物都表现出较高的抑制率，但该组中最具活性的成员是6-苯基-二氢吡喃-2,4-二酮。本文首次报道了二氢吡喃-2,4-二酮的抗氧化活性，并扩展了我们对与该组化合物相关的一系列有价值生物活性的认识。
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