合成及 N-芳基-1,4-二氢吡啶作为新型抗血脂异常和抗氧化剂的生物评价。
Synthesis and biological evaluation of N-aryl-1,4-dihydropyridines as novel antidyslipidemic and antioxidant agents.
机构信息
Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, UP 226001, India.
出版信息
Eur J Med Chem. 2010 Feb;45(2):501-9. doi: 10.1016/j.ejmech.2009.10.036. Epub 2009 Oct 31.
PMID:19962217
Abstract
N-aryl-1,4-dihydropyridines 2a-n were synthesized via iodine catalyzed three-component reaction of cinnamaldehydes, anilines and 2-keto esters in methanol. The synthesized compounds were screened for their antidyslipidemic and antioxidant activity in vivo and in vitro. Compounds 2a, 2g, and 2l have exhibited promising lipid and TG lowering activity, whereas compounds 2m and 2n have showed potent antioxidant activity.
摘要
N-芳基-1,4-二氢吡啶 2a-n 是通过碘催化肉桂醛、苯胺和 2-酮酯在甲醇中的三组分反应合成的。合成的化合物在体内和体外进行了抗血脂和抗氧化活性筛选。化合物 2a、2g 和 2l 表现出有希望的降低血脂和 TG 的活性，而化合物 2m 和 2n 表现出很强的抗氧化活性。
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