Park Eun-Jung, Min Hye-Young, Ahn Yong-Hyun, Bae Cheol-Man, Pyee Jae-Ho, Lee Sang Kook
College of Pharmacy, Ewha Womans University, 11-1 Daehyun-dong, Seodaemun-ku, Seoul 120-750, Republic of Korea.
Bioorg Med Chem Lett. 2004 Dec 6;14(23):5895-8. doi: 10.1016/j.bmcl.2004.09.022.
A series of natural stilbenoids, pinosylvin and its derivatives, were synthesized and evaluated for the inhibitory activity of prostaglandin E(2) production in lipopolysaccharide-induced RAW 264.7 cells. Potential inhibitors, including 3,5-dimethoxy-trans-stilbene and 3-hydroxy-5-benzyloxy-trans-stilbene, have been newly identified, and thus providing chemical leads for the further development of anti-inflammatory or cancer chemopreventive agents.
合成了一系列天然芪类化合物、白皮杉醇及其衍生物，并评估了它们在脂多糖诱导的RAW 264.7细胞中对前列腺素E(2)产生的抑制活性。新鉴定出了包括3,5-二甲氧基反式芪和3-羟基-5-苄氧基反式芪在内的潜在抑制剂，从而为进一步开发抗炎或癌症化学预防剂提供了化学先导物。
