Bakrim Saad, Machate Hamza, Benali Taoufiq, Sahib Nargis, Jaouadi Imane, Omari Nasreddine El, Aboulaghras Sara, Bangar Sneh Punia, Lorenzo José Manuel, Zengin Gokhan, Montesano Domenico, Gallo Monica, Bouyahya Abdelhakim
Molecular Engineering, Valorization and Environment Team, Polydisciplinary Faculty of Taroudant, Ibn Zohr University, Agadir B.P. 32/S, Morocco.
Laboratory of Biotechnology, Environment, Agri-Food and Health (LBEAS), Faculty of Sciences, University Sidi Mohamed Ben Abdellah (USMBA), Fez B.P. 1796, Morocco.
Plants (Basel). 2022 Jun 9;11(12):1541. doi: 10.3390/plants11121541.
Pinosylvin (3,5-dihydroxy--stilbene), a natural pre-infectious stilbenoid toxin, is a terpenoid polyphenol compound principally found in the Vitaceae family in the heartwood of spp. (e.g., ) and in pine leaf (). It provides defense mechanisms against pathogens and insects for many plants. Stilbenoids are mostly found in berries and fruits but can also be found in other types of plants, such as mosses and ferns. This review outlined prior research on pinosylvin, including its sources, the technologies used for its extraction, purification, identification, and characterization, its biological and pharmacological properties, and its toxicity. The collected data on pinosylvin was managed using different scientific research databases such as PubMed, SciFinder, SpringerLink, ScienceDirect, Wiley Online, Google Scholar, Web of Science, and Scopus. In this study, the findings focused on pinosylvin to understand its pharmacological and biological activities as well as its chemical characterization to explore its potential therapeutic approaches for the development of novel drugs. This analysis demonstrated that pinosylvin has beneficial effects for various therapeutic purposes such as antifungal, antibacterial, anticancer, anti-inflammatory, antioxidant, neuroprotective, anti-allergic, and other biological functions. It has shown numerous and diverse actions through its ability to block, interfere, and/or stimulate the major cellular targets responsible for several disorders.
白皮杉醇（3,5 - 二羟基 - 二苯乙烯）是一种天然的感染前芪类毒素，是一种萜类多酚化合物，主要存在于葡萄科植物的心材中（如 ）以及松叶中（ ）。它为许多植物提供针对病原体和昆虫的防御机制。芪类化合物大多存在于浆果和果实中，但也可在其他类型的植物中找到，如苔藓和蕨类植物。本综述概述了此前关于白皮杉醇的研究，包括其来源、用于提取、纯化、鉴定和表征的技术、其生物学和药理学特性以及其毒性。使用不同的科学研究数据库（如PubMed、SciFinder、SpringerLink、ScienceDirect、Wiley Online、Google Scholar、Web of Science和Scopus）管理收集到的关于白皮杉醇的数据。在本研究中，研究结果聚焦于白皮杉醇，以了解其药理和生物学活性以及其化学表征，从而探索其作为新型药物开发的潜在治疗方法。该分析表明，白皮杉醇对各种治疗目的具有有益作用，如抗真菌、抗菌、抗癌、抗炎、抗氧化、神经保护、抗过敏及其他生物学功能。它通过阻断、干扰和/或刺激导致多种疾病的主要细胞靶点，展现出众多且多样的作用。
