Delpapa E H, Edelstone D I, Milley J R, Balsan M
Department of Obstetrics, University of Pittsburgh School of Medicine, PA.
Am J Obstet Gynecol. 1992 Mar;166(3):1007-12. doi: 10.1016/0002-9378(92)91380-s.
The hypothesis of our study was that both the systemic and uteroplacental circulations would adapt to chronic maternal anemia to ensure that oxygen supply to maternal tissues would be adequate.
We measured cardiac output and uteroplacental blood flow and calculated systemic and uteroplacental oxygen delivery, extraction, and consumption in pregnant sheep that were anemic for 6 days (hematocrit 14%) and in normal sheep (hematocrit 28%).
When compared with normal pregnant sheep, anemic pregnant sheep had increases in cardiac output and uteroplacental blood flow, neither of which was sufficient to prevent systemic or uteroplacental oxygen delivery from decreasing. In spite of decreases in oxygen delivery, systemic and uteroplacental oxygen consumptions were maintained at normal levels because of increases in oxygen extraction.
Maternal systemic and uteroplacental circulations are capable of adapting well to chronic maternal anemia.
我们研究的假设是，全身循环和子宫胎盘循环都会适应慢性母体贫血，以确保母体组织的氧气供应充足。
我们测量了怀孕绵羊的心输出量和子宫胎盘血流量，并计算了贫血6天（血细胞比容14%）的怀孕绵羊和正常绵羊（血细胞比容28%）的全身及子宫胎盘氧输送、摄取和消耗。
与正常怀孕绵羊相比，贫血怀孕绵羊的心输出量和子宫胎盘血流量增加，但两者均不足以防止全身或子宫胎盘氧输送减少。尽管氧输送减少，但由于氧摄取增加，全身和子宫胎盘氧消耗维持在正常水平。
母体全身和子宫胎盘循环能够很好地适应慢性母体贫血。
