Yaris Fusun, Kadioglu Mine, Kesim Murat, Ulku Cunay, Yaris Ersin, Kalyoncu Nuri Ihsan, Unsal Mesut
Department of Family Medicine, School of Medicine, Karadeniz Technical University, TR-61187 Trabzon, Turkey.
Reprod Toxicol. 2004 Dec;19(2):235-8. doi: 10.1016/j.reprotox.2004.07.004.
Antidepressant drug choice in pregnancy is a complex problem especially for new drugs. Among 590 cases exposed to drugs during pregnancy who were followed by our center, 21 cases used newer antidepressants, i.e., venlafaxine, mirtazapine, nefazodone. We present the gestational findings and fetal outcomes of these cases. Ten cases had used venlafaxine, one case had used both venlafaxine and mirtazapine, eight had used mirtazapine alone or with some other drugs and two had used nefazodone, in the first trimester. Of the 21 cases, 17 (80.9%) had healthy babies, 3 (14.3%) decided to terminate the pregnancy, and 1 (4.8%) spontaneous abortion was observed in a case exposed to mirtazapine, alprazolam, diazepam and trifluoperazine. All obstetrical findings were normal during the pregnancy of each case. No congenital abnormality and developmental problem was observed in the babies followed up for 12 months. The aim of the present study is to contribute the data to the limited knowledge available in the literature regarding human pregnancy.
孕期抗抑郁药物的选择是一个复杂的问题，尤其是对于新药而言。在我们中心随访的590例孕期接触药物的病例中，有21例使用了新型抗抑郁药，即文拉法辛、米氮平、奈法唑酮。我们展示了这些病例的孕期情况及胎儿结局。10例使用了文拉法辛，1例同时使用了文拉法辛和米氮平，8例单独使用米氮平或与其他药物联用，2例在孕早期使用了奈法唑酮。在这21例中，17例（80.9%）产下健康婴儿，3例（14.3%）决定终止妊娠，1例（4.8%）在接触米氮平、阿普唑仑、地西泮和三氟拉嗪的病例中出现自然流产。每例患者孕期的所有产科检查结果均正常。在随访12个月的婴儿中未观察到先天性异常和发育问题。本研究的目的是为文献中关于人类孕期的有限知识提供数据。
