Ding Mei, Woo Wei-Meng, Chisholm Andrew D
Department of Molecular, Cell, and Developmental Biology, Sinsheimer Laboratories, University of California, Santa Cruz, CA 95064, USA.
Exp Cell Res. 2004 Nov 15;301(1):84-90. doi: 10.1016/j.yexcr.2004.08.017.
During Caenorhabditis elegans development, the process of epidermal elongation converts the bean-shaped embryo into the long thin shape of the larval worm. Epidermal elongation results from changes in the shape of epidermal cells, which in turn result from changes in the epidermal cytoskeleton, the extracellular matrix, and in cell-matrix adhesion junctions. Here, we review the roles of cytoskeletal filament systems in epidermal cell shape change during elongation. Genetic and cell biological analyses have established that all three major cytoskeletal filament systems (actin microfilaments, microtubules, and intermediate filaments (IFs)) play distinct and essential roles in epidermal cell shape change. Recent work has also highlighted the importance of communication between these systems for their integrated function in epidermal elongation. Epidermal cells undergo reciprocal interactions with underlying muscle cells, which regulate the position and function of IF-containing cell-matrix adhesion structures within the epidermis. Elongation thus exemplifies the reciprocal tissue interactions of organogenesis.
在秀丽隐杆线虫的发育过程中，表皮伸长过程将豆形胚胎转变为幼虫蠕虫的细长形状。表皮伸长源于表皮细胞形状的变化，而表皮细胞形状的变化又源于表皮细胞骨架、细胞外基质以及细胞 - 基质黏附连接的变化。在此，我们综述细胞骨架丝系统在伸长过程中表皮细胞形状变化中的作用。遗传和细胞生物学分析已证实，所有三种主要的细胞骨架丝系统（肌动蛋白微丝、微管和中间丝（IFs））在表皮细胞形状变化中发挥着独特且重要的作用。近期的研究还强调了这些系统之间的通讯对于它们在表皮伸长中的整合功能的重要性。表皮细胞与下方的肌肉细胞进行相互作用，这调节了表皮内含有中间丝的细胞 - 基质黏附结构的位置和功能。因此，伸长体现了器官发生过程中的相互组织作用。
