Hammerman Peter S, Fox Casey J, Thompson Craig B
Department of Cancer Biology and Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Trends Biochem Sci. 2004 Nov;29(11):586-92. doi: 10.1016/j.tibs.2004.09.008.
Two integral components of cellular transformation are increased cellular metabolism and apoptotic resistance. Recent progress in understanding the cellular functions of core apoptotic components and of growth factor-induced apoptotic regulatory proteins has indicated that the control of cellular metabolism and apoptosis are intertwined. There is growing evidence for connections between the regulation of both cellular bioenergetics and apoptosis and, thus, it is intriguing to explore the idea that growth factor regulation of cellular metabolism can directly affect cell survival.
细胞转化的两个不可或缺的组成部分是细胞代谢增加和凋亡抗性增强。在理解核心凋亡成分以及生长因子诱导的凋亡调节蛋白的细胞功能方面的最新进展表明，细胞代谢和凋亡的调控相互交织。越来越多的证据表明细胞生物能量学和凋亡的调控之间存在联系，因此，探讨生长因子对细胞代谢的调控可直接影响细胞存活这一观点很有意思。
