Whelan Jo
Drug Discov Today. 2004 Nov 1;9(21):907. doi: 10.1016/S1359-6446(04)03268-4.
Hydrocarbon stapling could enable peptides from the key domains of natural proteins to be used therapeutically. Using the technique on a peptide involved in apoptosis, researchers have succeeded in destroying cancer cells in a mouse model of leukaemia.
烃类环化修饰能够使源自天然蛋白质关键结构域的肽类用于治疗。研究人员将该技术应用于一种参与细胞凋亡的肽,成功在白血病小鼠模型中摧毁了癌细胞。