血清p53与膀胱癌：血清p53能否用作肿瘤标志物？
Serum p53 and bladder cancer: can serum p53 be used as a tumor marker?
作者信息
Malviya Vibhav, Singh Harbans, Dwivedi U S, Singh P B
机构信息
Department of Urology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221 005 India.
出版信息
Urol Res. 2004 Dec;32(6):391-4. doi: 10.1007/s00240-004-0415-9. Epub 2004 Oct 19.
The aim of this study was to find the correlation between serum p53 and carcinoma of the bladder and to investigate whether serum p53 protein can be used as a tumor marker for p53 gene alteration. The study included patients with carcinoma of the bladder and controls. Serum p53 protein estimation was done with an ELISA kit. There were 23 patients with superficial and 17 with invasive carcinoma. The median serum p53 was 31.5 U/ml in superficial and 41 U/ml in invasive cancer. This was significantly higher than the mean value (16.4 U/ml) of controls. Serum p53 rises in patients with carcinoma of the bladder and correlates with the grade of the disease . It can therefore be used as a tumor marker for bladder cancer.
本研究的目的是找出血清p53与膀胱癌之间的相关性，并研究血清p53蛋白是否可作为p53基因改变的肿瘤标志物。该研究纳入了膀胱癌患者和对照组。使用ELISA试剂盒测定血清p53蛋白。有23例浅表性癌患者和17例浸润性癌患者。浅表性癌患者血清p53的中位数为31.5 U/ml，浸润性癌患者为41 U/ml。这显著高于对照组的平均值（16.4 U/ml）。膀胱癌患者血清p53升高，且与疾病分级相关。因此，它可作为膀胱癌的肿瘤标志物。
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