Yalaz Mehmet, Arslan Mehmet T, Kurugöl Zafer
Department of Pediatrics, Ege University Faculty of Medicine, Izmir, Turkey.
Turk J Pediatr. 2004 Jul-Sep;46(3):265-7.
Thrombocytopenic purpura associated with brucellosis has been rarely reported in the world literature. Thrombocytopenic purpura is generally part of the array of manifestations of brucellosis such as fever, arthritis, malaise and hepatosplenomegaly. We describe a nine-year-old girl who presented with thrombocytopenic purpura as the sole manifestation of brucellosis, which resolved with anti-Brucella chemotherapy. Her physical examination was remarkable for hepatomegaly of 3 cm and splenomegaly of 2 cm palpable below the costal margin. Initial laboratory investigations revealed isolated thrombocytopenia with platelet count of 11,300/mm3 and positive serology for Brucella. Thrombocytopenia resolved promptly with proper antibiotics on 7th day of treatment. Brucellosis should be included in the differential diagnosis of thrombocytopenic purpura in Brucella-endemic areas.
血小板减少性紫癜合并布鲁氏菌病在世界文献中鲜有报道。血小板减少性紫癜通常是布鲁氏菌病一系列临床表现的一部分,如发热、关节炎、不适和肝脾肿大。我们描述了一名9岁女孩,她以血小板减少性紫癜作为布鲁氏菌病的唯一表现,经抗布鲁氏菌化疗后病情缓解。她的体格检查显示肝肿大3厘米,脾肿大2厘米,可在肋缘下触及。初步实验室检查发现孤立性血小板减少,血小板计数为11300/mm³,布鲁氏菌血清学检查呈阳性。治疗第7天使用适当抗生素后血小板减少症迅速缓解。在布鲁氏菌病流行地区,血小板减少性紫癜的鉴别诊断应包括布鲁氏菌病。