银翘挥发油与β-环糊精包合物常数的测定
[Determination of constant for the inclusion complex of Yinqiao volatile oil with beta-cyclodextrin].
作者信息
Ma Kun-Fang, Ren Yong, Wang Xuan, Mao Lin
机构信息
Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2004 Aug;29(8):739-42.
OBJECTIVE
To determine the constant for the inclusion complex of Yinqiao volatile oil with beta-cyclodextrin.
METHOD
The stability constant for the inclusion complex of Yinqiao the volatile oil with beta-cyclodextrin was detemined under multiwavelength by ultraviolet spectroscopy, and spectroscopy feature for inclusion complex was studied. The phase solubility-curve showed the inclusion proportion. The inclusion complex of Yinqiao the volatile oil with beta-cyclodextrin was prepared by saturated aqueous solution. The DTA spectroscopy of inclusion complex was different from not only oil with beta-cyclodextrin but also the mixture of them.
RESULT
The inclusion complex of Yinqiao the volatile oil with beta-cyclodextrin was formed. The experimental data of inclusion complex fitted well to the molar ratio of 1:1. There was good liner feature under multiwavelength of ultraviolet spectroscopy.
CONCLUSION
Adopting multiwavelength method may determine the appearant stability constant of multicomponential traditional drug. The determination of the stability constant of the inclusion complex can be used in traditional drug.
目的
测定银翘挥发油与β-环糊精包合物的常数。
方法
采用紫外光谱法在多波长下测定银翘挥发油与β-环糊精包合物的稳定常数，并研究包合物的光谱特征。相溶解度曲线显示包合比例。采用饱和水溶液法制备银翘挥发油与β-环糊精的包合物。包合物的差示热分析光谱不仅与油和β-环糊精不同，也与它们的混合物不同。
结果
形成了银翘挥发油与β-环糊精的包合物。包合物的实验数据与摩尔比1:1拟合良好。在紫外光谱的多波长下有良好的线性特征。
结论
采用多波长方法可测定多组分传统药物的表观稳定常数。包合物稳定常数的测定可应用于传统药物。
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