Elhadd T A, Kennedy G, Robb R, McLaren M, Jung R T, Belch J J F
Section of Vascular Biology and Medicine, University and Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland, UK.
Int Angiol. 2004 Jun;23(2):128-33.
Cell adhesion molecules may serve as markers of endothelial cell activation, and they may well have a role in the pathogenesis of atherosclerotic vascular disease in diabetes mellitus.
a cross sectional, comparative study.
a teaching University Hospital. Patients and controls. A cohort of diabetic patients with absent peripheral arterial pulses but no history of cardiovascular or cerebrovascular disease i.e. asymptomatic (n=29), median age 68 (36-80) years, (range), diabetes duration 10 (1-43) years and HbA1c 7.7% (4.8-9.6). They were compared to 12 age and sex matched normal non-diabetic controls.
none.
soluble cell adhesion molecules intercellular cell adhesion molecule-1 (ICAM-1) and E-selectin levels measured by ELISA methods.
The 29 patients with diabetes, as a whole, were found to have significantly higher median plasma sICAM-1 and sE-selectin of 283 ng/ml (154-1000) (range), and 65.8 ng/ml (20.6-145) vs 237 (147-312.4) and 37.7 (19.8-46.6) respectively, Mann Whitney U test p<0.02, and p<0.002. In the diabetic group, E-selectin correlated with ICAM-1, age and HbA1c: r=0.524 p<0.01, r=0.385 p<0.05 and r=0.393 p<0.05 respectively (Spearman correlation coefficient).
These results confirm that elevated levels of adhesion molecules, E-selectin and ICAM-1 occur in Type-2 diabetes early in the course of asymptomatic peripheral arterial occlusive disease, and this is related to glycemic control. This suggests that adhesion molecules may have a role in the pathogenesis of atherosclerotic vascular disease in diabetes.
细胞黏附分子可能作为内皮细胞活化的标志物，并且很可能在糖尿病患者动脉粥样硬化性血管疾病的发病机制中起作用。
一项横断面比较研究。
一所教学大学医院。患者与对照组。一组无外周动脉搏动但无心血管或脑血管疾病病史即无症状的糖尿病患者（n = 29），中位年龄68（36 - 80）岁（范围），糖尿病病程10（1 - 43）年，糖化血红蛋白7.7%（4.8 - 9.6）。将他们与12名年龄和性别匹配的正常非糖尿病对照者进行比较。
无。
采用酶联免疫吸附测定（ELISA）方法测量可溶性细胞黏附分子细胞间黏附分子 - 1（ICAM - 1）和E - 选择素水平。
总体上，29例糖尿病患者的血浆可溶性ICAM - 1和可溶性E - 选择素的中位水平显著更高，分别为283 ng/ml（154 - 1000）（范围）和65.8 ng/ml（20.6 - 145），而对照组分别为237（147 - 312.4）和37.7（19.8 - 46.6），曼 - 惠特尼U检验p < 0.02和p < 0.002。在糖尿病组中，E - 选择素与ICAM - 1、年龄和糖化血红蛋白相关：相关系数r分别为0.524 p < 0.01、0.385 p < 0.05和0.393 p < 0.05（斯皮尔曼相关系数）。
这些结果证实，在无症状外周动脉闭塞性疾病病程早期，2型糖尿病患者体内黏附分子E - 选择素和ICAM - 1水平升高，且这与血糖控制有关。这表明黏附分子可能在糖尿病患者动脉粥样硬化性血管疾病的发病机制中起作用。
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