Oslo Vascular Centre, Oslo University Hospital, Aker, Oslo, Norway.
Angiology. 2011 May;62(4):301-5. doi: 10.1177/0003319710385338.
Elevated plasma levels of vascular inflammatory markers have been reported in patients with peripheral arterial disease (PAD). We assessed the effect of supervised exercise training (ET) on vascular inflammation, hypothesizing that ET reduces plasma levels of the endothelial adhesion molecules E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-I (VCAM-I). Twenty-nine patients with PAD underwent a supervised ET program for 8 weeks. Before and after ET, walking distances (pain-free, PWD; maximal, MWD) were determined by a standard treadmill test. Plasma levels of E-selectin and ICAM-I were significantly reduced (E-selectin: 45.5-40.4 ng/mL, P = .013); ICAM-I: 342.0-298.0 ng/mL, P = .016). VCAM-1 levels were unchanged. Walking distances increased significantly (PWD: median 77-150 m, P < .001; MWD: median 306-535 m, P < .001). In conclusion, 8 weeks of ET in patients with PAD reduces plasma levels of the specific endothelium-derived inflammatory markers E-selectin and ICAM-I.
已有研究报道，外周动脉疾病（PAD）患者的血浆血管炎症标志物水平升高。我们评估了监督运动训练（ET）对血管炎症的影响，假设 ET 可降低内皮细胞黏附分子 E-选择素、细胞间黏附分子-1（ICAM-1）和血管细胞黏附分子-1（VCAM-1）的血浆水平。29 例 PAD 患者接受了 8 周的监督 ET 计划。在 ET 前后，通过标准跑步机测试确定步行距离（无痛，PWD；最大，MWD）。E-选择素和 ICAM-1 的血浆水平显著降低（E-选择素：45.5-40.4ng/mL，P=0.013）；ICAM-1：342.0-298.0ng/mL，P=0.016）。VCAM-1 水平不变。步行距离显著增加（PWD：中位数 77-150m，P<.001；MWD：中位数 306-535m，P<.001）。总之，PAD 患者 8 周的 ET 可降低特定的内皮源性炎症标志物 E-选择素和 ICAM-1 的血浆水平。
