Blann A D, McCollum C N
Department of Surgery, University Hospital of South Manchester, Didsbury, UK.
Thromb Haemost. 1994 Jul;72(1):151-4.
Soluble adhesion molecules E-selectin, intercellular adhesion molecule (sICAM) and vascular cell adhesion molecule (sVCAM) were measured alongside von Willebrand factor (vWf) in 40 patients with peripheral vascular disease (PVD), 43 with ischaemic heart disease (IHD) and in equal numbers of age and sex matched asymptomatic controls. Increased vWf was found in patients with IHD (p = 0.0008) and in patients with PVD (p = 0.0001) relative to their respective controls but levels did not differ between the two patient groups. Raised sICAM was found in both PVD (p = 0.0003) and IHD (p = 0.0059) compared to their respective controls and was higher in PVD than in IHD (p = 0.0088). In the subjects taken as a whole, there was no correlation between vWf and sICAM. Levels of soluble E-selectin and sVCAM did not differ in patients or controls. These data suggest that soluble ICAM may be useful as an index of endothelial cell activation in clinical manifestations of atherosclerosis.
在40例外周血管疾病（PVD）患者、43例缺血性心脏病（IHD）患者以及数量相等的年龄和性别匹配的无症状对照者中，同时检测了可溶性黏附分子E-选择素、细胞间黏附分子（sICAM）和血管细胞黏附分子（sVCAM）以及血管性血友病因子（vWf）。相对于各自的对照组，IHD患者（p = 0.0008）和PVD患者（p = 0.0001）的vWf升高，但两组患者之间的水平没有差异。与各自的对照组相比，PVD（p = 0.0003）和IHD（p = 0.0059）患者的sICAM均升高，且PVD患者的sICAM高于IHD患者（p = 0.0088）。在总体研究对象中，vWf与sICAM之间无相关性。患者或对照者的可溶性E-选择素和sVCAM水平无差异。这些数据表明，可溶性ICAM可能作为动脉粥样硬化临床表现中内皮细胞活化的一个指标。
