[来自麻风病患者的多重耐药麻风分枝杆菌]

[Multi-drug resistant Mycobacterium leprae from patients with leprosy].

作者信息

Maeda Shinji

机构信息

Department of Host Defense, Osaka City University Graduate School of Medicine, Japan.

出版信息

Nihon Hansenbyo Gakkai Zasshi. 2004 Sep;73(3):227-33. doi: 10.5025/hansen.73.227.

DOI:10.5025/hansen.73.227

PMID:15508725

Abstract

DNA sequences of Mycobacterium leprae in particular regions of the gyrA, rpoB, and folP genes responsible for resistance to new quinolones, rifampicin and dapsone, respectively, were analyzed. Among 88 isolates of M. leprae from leprosy patients in Japan, Haiti, Indonesia, Pakistan, and the Philippines, eleven isolates had mutational changes in 2 genes (resistance to 2 drugs), and 2 isolates (Shinsei-1 and Zensho-4) showed mutations in 3 genes (resistance to 3 drugs). These findings are suggesting emergence of multi-drug resistant M. leprae.

摘要

对麻风分枝杆菌gyrA、rpoB和folP基因特定区域的DNA序列进行了分析，这些区域分别与对新型喹诺酮类、利福平及氨苯砜的耐药性有关。在来自日本、海地、印度尼西亚、巴基斯坦及菲律宾麻风病人的88株麻风分枝杆菌分离株中，11株分离株在2个基因中有突变（对2种药物耐药），2株分离株（新生-1和全祥-4）在3个基因中显示有突变（对3种药物耐药）。这些发现提示出现了多药耐药的麻风分枝杆菌。