Berchtold E, Maibach R, Müller U
Allergy Unit, Zieglerspital, Bern, Switzerland.
Clin Exp Allergy. 1992 Jan;22(1):59-65. doi: 10.1111/j.1365-2222.1992.tb00115.x.
In a double-blind placebo-controlled trial on 52 patients with bee venom allergy we studied the effect of a pretreatment with terfenadine 120 mg twice daily on the occurrence of local and systemic allergic side effects from rush-immunotherapy. Large local reactions were significantly reduced by terfenadine pretreatment (P less than 0.01), while systemic side effects were observed with similar frequencies in both groups. Analysis of individual systemic allergic manifestations showed that cutaneous symptoms like itching (P less than 0.025) and urticaria/angioedema (P less than 0.05) were significantly reduced, while respiratory or cardiovascular symptoms were not influenced. A lower consumption of additional anti-allergic medication was found during terfenadine pretreatment (P less than 0.05). Pretreatment with antihistamines during immunotherapy may thus be helpful in the management of patients with cutaneous side effects.
在一项针对52名蜂毒过敏患者的双盲安慰剂对照试验中，我们研究了每日两次服用120毫克特非那定进行预处理，对速发型免疫疗法引起的局部和全身过敏副作用发生情况的影响。特非那定预处理可显著减少严重局部反应（P<0.01），而两组全身副作用的发生频率相似。对个体全身过敏表现的分析表明，皮肤症状如瘙痒（P<0.025）和荨麻疹/血管性水肿（P<0.05）显著减少，而呼吸道或心血管症状未受影响。在特非那定预处理期间，额外抗过敏药物的消耗量较低（P<0.05）。因此，免疫疗法期间使用抗组胺药进行预处理可能有助于治疗有皮肤副作用的患者。
