Wenz W, Friedrich B, Diener C, Schlenvoigt G, Jäger L, Strümpfel R
Z Gesamte Inn Med. 1984 Nov 1;39(21):530-3.
In 50 patients who had severe allergic general reactions after a bee sting clinical and immunological parameters were examined under the desensitisation with apitoxin. Under the introduction of the hospital treatment 25 patients showed side effects. 14 of these patients had milder general reactions also during the further continuation of the ambulatory treatment. In no case the treatment had to be stopped. The behaviour of the specific IgE and IgG antibodies does not allow a prognostic evidence concerning possible side effects and is little suited for the individual case also as objective parameter of success. 17 patients who during the first weeks after the beginning of the therapy spontaneously had been stung by a bee did not show any reactions or only reduced reactions. This result shows that the desensitization of desensitized patients gives a secure protection from life-threatening incidents. Open remains among others the problem of the objective judgment of the therapy and thus the question of the duration of the treatment.
在50名蜂蜇后发生严重过敏全身反应的患者中，在使用蜂毒进行脱敏治疗的过程中对临床和免疫学参数进行了检查。在住院治疗过程中，25名患者出现了副作用。其中14名患者在门诊治疗的后续持续过程中也出现了较轻的全身反应。在任何情况下治疗都无需停止。特异性IgE和IgG抗体的表现无法为可能的副作用提供预后证据，也不太适合作为个体病例成功的客观参数。17名在治疗开始后的头几周内被蜜蜂自发蜇伤的患者未出现任何反应或仅出现减轻的反应。这一结果表明，脱敏患者的脱敏治疗能提供防止危及生命事件的可靠保护。此外，治疗的客观判断问题以及治疗持续时间的问题仍然悬而未决。
