Ugboko Vincent Ifechukwukwu, Oginni Fadekemi Olufunmilayo, Adelusola Kayode A, Durosinmi Muheez A
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria.
J Oral Maxillofac Surg. 2004 Nov;62(11):1347-50. doi: 10.1016/j.joms.2004.07.003.
In this study, we sought to determine the occurrence of primary non-Hodgkins lymphoma (NHL) in the oral and maxillofacial region among Nigerians.
We retrospectively studied hospital records that included radiographs of all patients with a histopathologically confirmed diagnosis of NHL in the Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria, between January 1992 and December 1997. Data were expressed as mean +/- SD or number (%).
During the study period, 66 cases of NHL were recorded. Seventeen patients had concomitant extranodal lymphomas involving the gastrointestinal tract, nasopharynx, skin, lungs, kidney, and thyroid, in descending order. Three patients (4.5%) presented primarily with extranodal oral and maxillofacial disease. The ages of these patients ranged from 18 to 50 years (mean +/- SD, 32.3 +/- 16.3 years; median, 29 years). Within the same period, there were 121 cases of Burkitts lymphoma. The onset of lesions varied from 6 to 20 weeks. Two patients had intermediate-grade lesions; the remainder had low-grade lesions. Two presented with stage II disease, and the remainder were stage I. All of the patients had chemotherapy with remission of their lesions but were followed up to 6 months. Most of them did not complete the treatment cycles due to financial and social constraints.
The rarity of primary NHL of oral and maxillofacial region has been aptly shown in this study. The need for the establishment of an effective oncology policy with the active collaboration of voluntary agencies is emphasized. This would ensure ready availability of the required chemotherapeutic agents and hospital care at affordable costs.
在本研究中，我们试图确定尼日利亚人口腔颌面部原发性非霍奇金淋巴瘤（NHL）的发病情况。
我们回顾性研究了1992年1月至1997年12月期间在尼日利亚伊费奥巴费米·阿沃洛沃大学教学医院经组织病理学确诊为NHL的所有患者的医院记录，其中包括X光片。数据以均值±标准差或例数（%）表示。
在研究期间，共记录了66例NHL病例。17例患者伴有结外淋巴瘤，累及胃肠道、鼻咽部、皮肤、肺、肾和甲状腺，按降序排列。3例患者（4.5%）主要表现为结外口腔颌面部疾病。这些患者的年龄在18岁至50岁之间（均值±标准差，32.3±16.3岁；中位数，29岁）。同一时期，有121例伯基特淋巴瘤病例。病变出现时间为6至20周不等。2例患者为中级病变；其余为低级病变。2例为II期疾病，其余为I期。所有患者均接受化疗，病变缓解，但随访至6个月。由于经济和社会限制，大多数患者未完成治疗周期。
本研究充分显示了口腔颌面部原发性NHL的罕见性。强调需要在志愿机构的积极协作下制定有效的肿瘤学政策。这将确保以可承受的成本随时获得所需的化疗药物和医院护理。
