Vyas Akansha, Chug Ashi, Sehrawat Amit, Simre Saurabh, Porwal Jasmine, Kolse Preeti
Department of Oral and Maxillofacial Surgery, All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand 249203 India.
Department of Medical Oncology Haematology, All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand 249203 India.
J Maxillofac Oral Surg. 2024 Aug;23(4):1022-1025. doi: 10.1007/s12663-024-02174-9. Epub 2024 Apr 8.
Extranodal non-Hodgkin's lymphoma (NHL) afflicting the head and neck region is rare, accounting for only about 5%. Diffuse large B-cell lymphoma (DLBCL) is the most common type of NHL affecting the oral cavity. Due to its variable clinical presentation and non-pathognomic course, it can be easily misdiagnosed with overlapping characteristics to common oral pathologies. In the present case, the authors report an unusual presentation of DLBCL and highlight the significant diagnostic challenge encountered by the clinician. In our case, osteonecrosis of the maxilla with soft tissue swelling misleads the diagnosis of chronic osteomyelitis. However, further, work-up was pursued, and the patient was managed successfully with chemotherapy and is currently disease-free for the past 1 year. An accurate clinico-radiological diagnosis with histopathological confirmation is emphasized to deliver a potentially curative treatment in a timely manner.
累及头颈部区域的结外非霍奇金淋巴瘤（NHL）较为罕见，仅占约5%。弥漫性大B细胞淋巴瘤（DLBCL）是影响口腔的最常见的NHL类型。由于其临床表现多样且病程无特异性，它很容易与常见口腔病变具有重叠特征而被误诊。在本病例中，作者报告了DLBCL的一种不寻常表现，并强调了临床医生所面临的重大诊断挑战。在我们的病例中，上颌骨骨坏死伴软组织肿胀误导了慢性骨髓炎的诊断。然而，进一步进行了检查，患者通过化疗成功得到治疗，目前已无病生存1年。强调通过组织病理学确认进行准确的临床放射学诊断，以便及时提供潜在的治愈性治疗。
