Chacon Guillermo E, Ellis James P, Kalmar John R, McGlumphy Edwin A
Section of Oral and Maxillofacial Surgery, Pathology and Anesthesiology, College of Dentistry, The Ohio State University, Columbus, USA.
J Oral Maxillofac Surg. 2004 Nov;62(11):1396-402. doi: 10.1016/j.joms.2004.06.046.
The purpose of this study is to test bioresorbable screws as an alternative to titanium screw graft fixation. When cortical onlay grafts are used, it is necessary to rigidly immobilize them with titanium screws into the recipient site. The screws must be removed before placing implants into this site. Bioresorbable screws may be an alternative to titanium fixation, eliminating the additional morbidity associated with this.
Fifteen New Zealand White rabbits were divided into 3 groups. Bilateral tibial onlay bone grafts were placed in the mandible and secured using titanium fixation, bioresorbable fixation, or no fixation. After 6 weeks, all grafted sites were harvested. Hematoxylin-eosin and Giemsa staining were performed to evaluate inflammation, graft integration, and thickness.
The treatment groups showed evidence of consolidation under light microscopy. Smooth integration of the graft borders with the recipient bone was identified. No integration was seen in the control group. The average thickness of the grafted sites was: 1) bioresorbable, 2.28 mm; 2) titanium, 1.87 mm; and 3) control, 1.06 mm. The differences were statistically significant (P = .0004) between the titanium group and the control group, as well as between the bioresorbable and the control group (P = .01). There was no statistically significant difference between the 2 treatment groups (P = .19).
The overall thickness of the treatment specimens was greater than that of the control group. The bioresorbable group showed graft integration equal to that of the titanium group, making it an adequate alternative for graft fixation.
本研究的目的是测试生物可吸收螺钉作为钛螺钉移植固定的替代物。当使用皮质骨贴附移植时，有必要用钛螺钉将其牢固地固定在受体部位。在该部位植入种植体之前必须取出螺钉。生物可吸收螺钉可能是钛固定的替代物，可消除与之相关的额外发病率。
15只新西兰白兔分为3组。将双侧胫骨贴附骨移植置于下颌骨，分别采用钛固定、生物可吸收固定或不固定。6周后收获所有移植部位。进行苏木精-伊红和吉姆萨染色以评估炎症、移植融合和厚度。
治疗组在光学显微镜下显示有愈合迹象。可见移植边缘与受体骨平滑融合。对照组未见融合。移植部位的平均厚度为：1）生物可吸收组，2.28毫米；2）钛组；1.87毫米；3）对照组，1.06毫米。钛组与对照组之间以及生物可吸收组与对照组之间的差异具有统计学意义（P = 0.0004）（P = 0.01）。两个治疗组之间无统计学显著差异（P = 0.19）。
治疗标本的总体厚度大于对照组。生物可吸收组显示出与钛组相同的移植融合情况，使其成为移植固定的合适替代物。
