t(2;14)(p13;q32)：淋巴细胞白血病中一种反复出现的异常情况。一项儿科肿瘤学组的研究。
t(2;14)(p13;q32): a recurring abnormality in lymphocytic leukemia. A Pediatric Oncology Group study.
作者信息
Watson M S, Land V J, Carroll A J, Pullen J, Borowitz M J, Link M P, Amylon M, Behm F G
机构信息
Division of Medical Genetics, St. Louis Children's Hospital, Washington University School of Medicine, Missouri 63110.
出版信息
Cancer Genet Cytogenet. 1992 Feb;58(2):121-4. doi: 10.1016/0165-4608(92)90096-q.
Chromosome banding studies of 1,411 children with newly diagnosed acute lymphocytic leukemia (ALL) identified two patients with the t(2;14)(p13;q32) chromosome abnormality and a third patient with a complex three-way translocation involving the same breakpoints on chromosomes 2 and 14 but also involving chromosome 12 at band q11. The three cases demonstrated variability of immunophenotypes: one was a T-cell ALL, and two were early pre-B ALLs. All three patients achieved complete remissions and have remained in remission for 14-19 months.
对1411例新诊断的急性淋巴细胞白血病（ALL）患儿进行的染色体显带研究发现，有2例患者存在t(2;14)(p13;q32)染色体异常，另有1例患者存在复杂的三向易位，涉及染色体2和14上相同的断点，但也涉及染色体12的q11带。这3例病例表现出免疫表型的差异：1例为T细胞ALL，2例为早期前B-ALL。所有3例患者均实现完全缓解，且已维持缓解状态14至19个月。
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