Translocation (Y;2) in childhood acute lymphoblastic leukemia.
作者信息
Kowalczyk J R, Chobotow M, Sladkowska G
机构信息
Institute of Pediatrics, Lublin, Poland.
出版信息
Cancer Genet Cytogenet. 1991 Oct 1;56(1):7-10. doi: 10.1016/0165-4608(91)90356-y.
PMID:1747871
Abstract
A case of ALL in a 2 1/2-year-old boy with fatal outcome is presented. Cytogenetic analysis revealed a hypodiploid karyotype: 45,X-Y,-2,+der (2)t(Y;2),-12,i(17q),+mar. Some metaphases represented a sideline with 44 chromosomes and monosomy 8 was a consistent anomaly. These findings are rather uncommon in ALL. Hypodiploidy and the translocation, however, indicated poor prognosis in this case.
摘要
Zotero 插件