Maciorkowska Elzbieta, Kaczmarski Maciej, Kowalczuk Jarosław, Kondej-Muszyńska Katarzyna, Roszko Izabela, Cieśla Justyna, Zielińska Agata, Musaibili Sami
III Klinika Chorób Dzieci AM w Białymstoku.
Pol Merkur Lekarski. 2004 Jun;16(96):543-6.
In literature and clinical findings, the attention has been turned to the resistance to the antibiotics used in Helicobacter pylori eradication, especially metronidazole and clarithromycin. Drug-resistance was evaluated in 50 children. Primary drug-resistance to the antibiotics used in eradications was determined in this group, and additionally, in 18 children who were subjected twice to unsuccessful eradicative therapy. The highest secondary resistance to metronidazole up to 72.0% was found among conventionally used antibiotics. Primary resistance of H. pylori rods to clarithromycin was also high and equaled 25.0%. However, in our study secondary resistance to macrolides was about 66.0%. In our study combined primary resistance to clarithromycin and metronidazole was about 7.2%. There was not H. pylori rods resistance to amoxicillin and tetracyclines.
在文献和临床研究结果中，注意力已转向幽门螺杆菌根除治疗中使用的抗生素耐药性问题，尤其是甲硝唑和克拉霉素。对50名儿童的耐药性进行了评估。在该组中确定了根除治疗中使用的抗生素的原发性耐药性，此外，还对18名接受两次根除治疗均未成功的儿童进行了评估。在常用抗生素中，发现对甲硝唑的继发性耐药性最高，可达72.0%。幽门螺杆菌对克拉霉素的原发性耐药性也很高，为25.0%。然而，在我们的研究中，对大环内酯类的继发性耐药性约为66.0%。在我们的研究中，对克拉霉素和甲硝唑的联合原发性耐药性约为7.2%。幽门螺杆菌对阿莫西林和四环素没有耐药性。
