波兰幽门螺杆菌的抗菌药物耐药性：一项多中心研究。
Antimicrobial resistance of Helicobacter pylori in Poland: a multicentre study.
作者信息
Dzierzanowska-Fangrat Katarzyna, Rozynek Elzbieta, Celińska-Cedro Danuta, Jarosz Mirosław, Pawłowska Jolanta, Szadkowski Aleksander, Budzyńska Agnieszka, Nowak Jan, Romańczuk Wrzesław, Prosiecki Ryszard, Jóźwiak Paulina, Dzierzanowska Danuta
机构信息
Department of Clinical Microbiology and Immunology, The Children's Memorial Health Institute, Aleja Dzieci Polskich 20, 04-730 Warsaw, Poland.
出版信息
Int J Antimicrob Agents. 2005 Sep;26(3):230-4. doi: 10.1016/j.ijantimicag.2005.06.015.
The resistance of Helicobacter pylori to antimicrobials, known to be increasing in many countries, is an important factor compromising the efficacy of eradication therapy. Therefore, our study aimed at analysing the current susceptibility status of H. pylori in Poland. A total of 337 H. pylori isolates were cultured from children (N=179) and adults (N=158) from various regions of the country from January 2001 to December 2004. All strains were susceptible to amoxicillin and tetracycline. The overall resistance to clarithromycin (CL) was 28%, but there were significant differences between the centres (ranging from 0% to 33%) and between child and adult isolates (28% versus 15%, respectively; P=0.01) for primary a resistance. Altogether, 46% of H. pylori isolates were resistant to metronidazole (MTZ) and 20% of isolates were simultaneously resistant to CL and MTZ.
幽门螺杆菌对抗菌药物的耐药性在许多国家呈上升趋势，这是影响根除治疗效果的一个重要因素。因此，我们的研究旨在分析波兰目前幽门螺杆菌的药敏状况。2001年1月至2004年12月期间，从该国不同地区的儿童（n = 179）和成人（n = 158）中总共培养出337株幽门螺杆菌分离株。所有菌株对阿莫西林和四环素敏感。对克拉霉素（CL）的总体耐药率为28%，但各中心之间（范围从0%至33%）以及儿童和成人分离株之间（分别为28%和15%；P = 0.01）的原发性耐药存在显著差异。总共有46%的幽门螺杆菌分离株对甲硝唑（MTZ）耐药，20%的分离株同时对CL和MTZ耐药。
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